Hnf4a | hepatic nuclear factor 4, alpha
Physiological systems
22 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Endocrine/exocrine gland Growth/size/body region Vision/eye Cardiovascular system
17 No significant impact
2 Not tested
Data collections
Gene metrics:14Significant phenotypes
6Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| increased circulating cholesterol level | 1 supporting dataset | Hnf4atm1b(EUCOMM)Hmgu | heterozygote | Early adult | 7.53x10-12 | ||
| increased total retina thickness | 1 supporting dataset | Hnf4atm1b(EUCOMM)Hmgu | heterozygote | Early adult | 6.73x10-5 | ||
| enlarged thyroid gland | 2 supporting datasets | Hnf4atm1b(EUCOMM)Hmgu | heterozygote | Late adult | N/A * | ||
| increased circulating HDL cholesterol level | 1 supporting dataset | Hnf4atm1b(EUCOMM)Hmgu | heterozygote | Early adult | 6.85x10-13 | ||
| increased circulating calcium level | 1 supporting dataset | Hnf4atm1b(EUCOMM)Hmgu | heterozygote | Late adult | 1.32x10-7 | ||
| increased circulating bilirubin level | 1 supporting dataset | Hnf4atm1b(EUCOMM)Hmgu | heterozygote | Early adult | 8.71x10-7 | ||
| decreased circulating creatinine level | 1 supporting dataset | Hnf4atm1b(EUCOMM)Hmgu | heterozygote | Late adult | 6.95x10-7 | ||
| abnormal retina blood vessel morphology | 1 supporting dataset | Hnf4atm1b(EUCOMM)Hmgu | heterozygote | Early adult | 1.21x10-8 | ||
| abnormal retina vasculature morphology | 1 supporting dataset | Hnf4atm1b(EUCOMM)Hmgu | heterozygote | Early adult | 2.17x10-9 | ||
| increased circulating cholesterol level | 1 supporting dataset | Hnf4atm1b(EUCOMM)Hmgu | heterozygote | Late adult | 1.63x10-6 |
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Human diseases caused by Hnf4a mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Hnf4a.
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| Hnf4atm1(EGFP/cre/ERT2)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Hnf4atm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Hnf4atm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Hnf4atm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Hnf4atm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Hnf4atm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |