Hnf4a | hepatic nuclear factor 4, alpha

GeneMGI:109128Synonyms: Nuclear receptor 2A1, MODY1, +6 more

Physiological systems

22 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Endocrine/exocrine gland Growth/size/body region Vision/eye Cardiovascular system

17 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:14Significant phenotypes

6Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:

Life Stage:



increased circulating cholesterol level	1 supporting dataset	Hnf4a^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	7.53x10^-12
increased total retina thickness	1 supporting dataset	Hnf4a^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	6.73x10^-5
enlarged thyroid gland	2 supporting datasets	Hnf4a^{tm1b(EUCOMM)Hmgu}	heterozygote	Late adult	N/A ^*
increased circulating HDL cholesterol level	1 supporting dataset	Hnf4a^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	6.85x10^-13
increased circulating calcium level	1 supporting dataset	Hnf4a^{tm1b(EUCOMM)Hmgu}	heterozygote	Late adult	1.32x10^-7
increased circulating bilirubin level	1 supporting dataset	Hnf4a^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	8.71x10^-7
decreased circulating creatinine level	1 supporting dataset	Hnf4a^{tm1b(EUCOMM)Hmgu}	heterozygote	Late adult	6.95x10^-7
abnormal retina blood vessel morphology	1 supporting dataset	Hnf4a^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.21x10^-8
abnormal retina vasculature morphology	1 supporting dataset	Hnf4a^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.17x10^-9
increased circulating cholesterol level	1 supporting dataset	Hnf4a^{tm1b(EUCOMM)Hmgu}	heterozygote	Late adult	1.63x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

Download data as:

Rows per page:

‌



‌	‌	‌	‌	‌	‌	‌	‌	‌	‌

* This parameter was manually assessed for significance.

Download data as:

lacZ Expression

No adult expression data available for Hnf4a.

Associated images

Loading...

Histopathology

There is no histopathology data found for Hnf4a.

IMPC related publications

Loading...

External links

No external links available for Hnf4a.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.



*Hnf4a^{tm1(EGFP/cre/ERT2)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Hnf4a^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Hnf4a^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Hnf4a^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Hnf4a^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Hnf4a^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

My Genes