Hnf4a | hepatic nuclear factor 4, alpha

GeneMGI:109128Synonyms: Nuclear receptor 2A1, MODY1, +6 more

Physiological systems

22 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Endocrine/exocrine gland Growth/size/body region Vision/eye Cardiovascular system

17 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:14Significant phenotypes

6Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:

Life Stage:



increased circulating cholesterol level	1 supporting dataset	Hnf4a^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	7.53x10^-12
increased total retina thickness	1 supporting dataset	Hnf4a^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	6.73x10^-5
enlarged thyroid gland	2 supporting datasets	Hnf4a^{tm1b(EUCOMM)Hmgu}	heterozygote	Late adult	N/A ^*
increased circulating HDL cholesterol level	1 supporting dataset	Hnf4a^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	6.85x10^-13
increased circulating calcium level	1 supporting dataset	Hnf4a^{tm1b(EUCOMM)Hmgu}	heterozygote	Late adult	1.32x10^-7
increased circulating bilirubin level	1 supporting dataset	Hnf4a^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	8.71x10^-7
decreased circulating creatinine level	1 supporting dataset	Hnf4a^{tm1b(EUCOMM)Hmgu}	heterozygote	Late adult	6.95x10^-7
abnormal retina blood vessel morphology	1 supporting dataset	Hnf4a^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.21x10^-8
abnormal retina vasculature morphology	1 supporting dataset	Hnf4a^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.17x10^-9
increased circulating cholesterol level	1 supporting dataset	Hnf4a^{tm1b(EUCOMM)Hmgu}	heterozygote	Late adult	1.63x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Hnf4a.

Associated images

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Histopathology

There is no histopathology data found for Hnf4a.

IMPC related publications

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External links

No external links available for Hnf4a.

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*Hnf4a^{tm1(EGFP/cre/ERT2)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell mouse
*Hnf4a^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Hnf4a^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Hnf4a^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Hnf4a^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell
*Hnf4a^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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